The technical note of Lam et al1 on the pragmatic or point-of-care clinical trial (POC-CT) design offers valuable insights into a nascent area of research in athletic training. Although the authors did an excellent job detailing the role and advantages of and considerations for the POC-CT design in athletic training, the introduction of the POC-CT is a small component of a growing approach across health care using information from “real-world” encounters for evidence generation. This approach, known as Real-World Evidence (RWE), could lead to novel applications of health care delivery and evidence generation. This commentary is